Estrogens, Progestogens, Normal Breast Cell Proliferation, and Breast Cancer Risk
Malcolm C. Pike, Darcy V. Spicer, Laila Dahmoush, and Michael F. Press
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Article topics:
- Oncology..Incidence and Mortality of Breast Cancer
- Oncology..Epidemiology, Causes, and Risk Factors of Breast Cancer
- Medicine..Breast Issues
- Oncology..Epidemiology
- Medicine..Menopause
- Oncology..Environmental/Lifestyle Causes of Breast Cancer
- Oncology..Diet and Nutrition
- Oncology..Breast Cancer
- Oncology..Medroxyprogesterone
- Oncology..Incidence
- Oncology..Hormonal Causes of Cancer
- Oncology..Treatment Options for Breast Cancer
- Physiology..Estradiol
- Medicine..Progesterone
- Medicine..Obesity
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||||
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||||
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||||
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||||
![]() |
M. D. Gammon, M. S. Wolff, A. I. Neugut, S. M. Eng, S. L. Teitelbaum, J. A. Britton, M. B. Terry, B. Levin, S. D. Stellman, G. C. Kabat, et al. Environmental Toxins and Breast Cancer on Long Island. II. Organochlorine Compound Levels in Blood Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 686 - 697. [Abstract] [Full Text] [PDF] |
||||
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||||
![]() |
S. W. Fletcher and G. A. Colditz Failure of Estrogen Plus Progestin Therapy for Prevention JAMA, July 17, 2002; 288(3): 366 - 368. [Full Text] [PDF] |
||||
![]() |
B. S. Han, K. Fukamachi, N. Takasuka, T. Ohnishi, M. Maeda, T. Yamasaki, and H. Tsuda Inhibitory effects of 17{beta}-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats Carcinogenesis, July 1, 2002; 23(7): 1209 - 1215. [Abstract] [Full Text] [PDF] |
||||
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||||
![]() |
S. C. Hewitt, W. P. Bocchinfuso, J. Zhai, C. Harrell, L. Koonce, J. Clark, P. Myers, and K. S. Korach Lack of Ductal Development in the Absence of Functional Estrogen Receptor {alpha} Delays Mammary Tumor Formation Induced by Transgenic Expression of ErbB2/neu Cancer Res., May 1, 2002; 62(10): 2798 - 2805. [Abstract] [Full Text] [PDF] |
||||
![]() |
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||||
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J. D. Peck, B. S. Hulka, C. Poole, D. A. Savitz, D. Baird, and B. E. Richardson Steroid Hormone Levels during Pregnancy and Incidence of Maternal Breast Cancer Cancer Epidemiol. Biomarkers Prev., April 1, 2002; 11(4): 361 - 368. [Abstract] [Full Text] [PDF] |
||||
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C.-L. Chen, N. S. Weiss, P. Newcomb, W. Barlow, and E. White Hormone Replacement Therapy in Relation to Breast Cancer JAMA, February 13, 2002; 287(6): 734 - 741. [Abstract] [Full Text] [PDF] |
||||
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||||
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![]() |
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