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Epidemiologic Reviews 24:269-279 (2002)
© 2002 by the Johns Hopkins Bloomberg School of Public Health

Blood Transfusions and Non-Hodgkin’s Lymphoma

Eric J. Chow1 and Elizabeth A. Holly2,3

1 University of California School of Medicine, San Francisco, CA. 2 Department of Epidemiology and Biostatistics, University of California School of Medicine, San Francisco, CA. 3 Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA.

Received for publication December 11, 2001; accepted for publication September 13, 2002.


Abbreviations: AIDS, acquired immunodeficiency syndrome; HIV, human immunodeficiency virus; SEER, Surveillance, Epidemiology, and End Results; Th-1, T-cell helper-1; Th-2, T-cell helper-2.

The first 150 words of the full text of this article appear below.


    INTRODUCTION
 
Background

Non-Hodgkin’s lymphoma is the fifth most frequently diagnosed cancer in the United States, with 53,900 new cases expected in 2002 (1). The incidence of non-Hodgkin’s lymphoma in the United States and western Europe has risen by at least 100 percent over the past five decades, with annual increases in incidence averaging 3–4 percent since the 1970s (2, 3). According to the Surveillance, Epidemiology, and End Results (SEER) cancer registry, the age-adjusted annual incidence rate from 1990 to 1997 in the United States was 15.5 per 100,000 population (4). This increase has involved all adult age groups, both sexes, and most geographic areas (2, 3, 5). Overall, incidence rates increase with age, are higher in men than in women, and are higher in Caucasians than in persons of other races/ethnicities (6). However, while incidence rates among Caucasians increased . . . [Full Text of this Article]

Blood transfusion as a risk factor


    OVERVIEW OF ANALYTICAL STUDIES
 
Cohort studies

Case-control studies

Summary of non-Hodgkin’s lymphoma subtype analysis


    DISCUSSION
 
Study design and potential biases

Exposure assessment

Evaluation of confounders

Assessment of non-Hodgkin’s lymphoma subtype


    PUBLIC HEALTH IMPLICATIONS
 

    ACKNOWLEDGMENTS
 

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