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Epidemiologic Reviews Advance Access published online on May 2, 2007
Epidemiologic Reviews, doi:10.1093/epirev/mxm002
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Epidemiologic Reviews Copyright © 2007 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

Article

Abdominal Obesity and Fatty Liver

MU Jakobsen1,2,3, T Berentzen1, TIA Sørensen1 and K Overvad2,3

1 Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark
2 Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
3 Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

Correspondence to Dr. Marianne Uhre Jakobsen, Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Sdr. Skovvej 15, Box 365, 9100 Aalborg, Denmark (e-mail: muj{at}dce.au.dk).

accepted for publication March 1, 2007.

It has been hypothesized that visceral fat releases free fatty acids and adipokines and thereby exposes the liver to fat accumulation. The authors aimed to evaluate current epidemiologic evidence for an association between abdominal fat and liver fat content. Clinical and epidemiologic studies with data on abdominal fat and liver fat content were reviewed. Studies using waist circumference to estimate abdominal fat mass suggested a direct association between abdominal fat and liver fat content. Studies using imaging methods suggested a direct association between intraabdominal fat and liver fat content, but not between subcutaneous abdominal fat and liver fat content. In conclusion, clinical and epidemiologic studies of abdominal fat and liver fat content suggest a direct association between abdominal fat and liver fat content which is probably accounted for by visceral fat. However, results from the included studies do not allow strong conclusions regarding the temporal sequence of events. Future longitudinal studies are recommended to obtain additional information on associations and mechanisms. Both abdominal fat depots and other body compartments of interest should be included to further investigate the association between specific fat depots and liver fat content. Biomarkers may provide insight into underlying mechanisms.

abdominal fat • adiposity • fatty liver • intra-abdominal fat • obesity • subcutaneous fat, abdominal

NAFLD, nonalcoholic fatty liver disease


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